By David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)
This first version of the textbook “Adrenocortical Carcinoma: simple Sciences and scientific techniques” presents a concise compilation of suitable facts advancing our present figuring out of this infrequent melanoma. Chapters are devoted to quite a few facets of either the elemental biology and the medical technological know-how on the subject of adrenocortical carcinoma (ACC). specialist clinicians introduce the reader to present state of the art scientific care of sufferers with ACC. As a substantial physique of information on ACC has gathered during the last a long time, specialist scientists have authored extra sections that function a reference resource for the skilled researcher in addition to an advent for the trainee within the laboratory or health facility. scientific themes span the epidemiology, analysis and treatment of ACC. medical themes parts span the pathology and pathophysiology of ACC with a distinct concentrate on experimental versions of adrenocortical tumors and up to date advances within the genetic points and signaling pathways in ACC. The content material of this publication was once compiled and edited with the motive of facilitating the interpretation of information into destiny diagnostic and healing instruments that may finally increase sufferer care.
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Therefore, purely aldosterone-secreting adrenal tumors <4 cm are suggestive of a benign adenoma. Of special importance is the exclusion of a pheochromocytoma. In the past decade, measurement of metanephrines (either as free metanephrine in plasma or as fractionated metanephrines in 24-h urine) has become the method of choice for the exclusion of pheochromocytoma [49–54]. Only in patients with indisputable adrenocortical steroid excess one might skip this analysis. As discussed above, ACC may rarely produce other hormones like ADH, renin, inhibin, or calcitonin.
5 Associated Malignancies In 1983, Nader et al. 5%) had second primary cancers that were histologically different from ACC. 4%) suffered from a second primary malignancy, including four patients with two different primary tumors. However, no specific pattern of associated tumors could be detected, and up to now no specific germline mutations have been identified in these patients. References 1. Bovio S et al (2006) Prevalence of adrenal incidentaloma in a contemporary computerized tomography series.
Favia G et al (2001) Adrenocortical carcinoma: is prognosis different in nonfunctioning tumors? Results of surgical treatment in 31 patients. World J Surg 25(6):735–738 12. Pommier RF, Brennan MF (1992) An eleven-year experience with adrenocortical carcinoma. Surgery 112(6):963–970; discussion 970–971 13. Vassilopoulou-Sellin R, Schultz PN (2001) Adrenocortical carcinoma. Clinical outcome at the end of the 20th century. Cancer 92(5):1113–1121 44 B. Allolio and M. Fassnacht 14. Wajchenberg B et al (2000) Adrenocortical carcinoma: clinical and laboratory observations.