By Christopher R. Jacobs, Daniel J. Kelly (auth.), Paulo R. Fernandes, Paulo Jorge Bártolo (eds.)
This ebook offers a suite of chapters describing the cutting-edge on computational modelling and fabrication in tissue engineering.
Tissue Engineering is a multidisciplinary box related to scientists from assorted fields. the advance of mathematical equipment is kind of appropriate to appreciate cellphone biology and human tissues in addition to version, layout and fabricate optimized and shrewdpermanent scaffolds.
The bankruptcy authors are the prestigious keynote audio system on the first Eccomas thematic convention on Tissue Engineering the place the emphasis used to be on mathematical and computational modeling for scaffold layout and fabrication. this actual zone of tissue engineering, whose aim is to acquire substitutes for demanding tissues akin to bone and cartilage, is becoming in value.
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Additional info for Advances on Modeling in Tissue Engineering
Prediction of bone adaptation using damage accumulation. J Biomech 27:1067-1076. 11. Hart RT, Fritton SP (1997) Introduction to finite element based simulation of functional adaptation of cancellous bone. Forma 12:277-299. 12. Jacobs CR, Simo JC, Beaupré GS, Carter DR (1997) Adaptive bone remodeling incorporating simultaneous density and anisotropy considerations. J Biomech 30:603-613. 13. Fernandes P, Rodrigues H, Jacobs C (1999) A model of bone adaptation using a global optimization criterion based on the trajectorial theory of Wolff.
In: Perdersen P, Bendsoe MP (ed), Synthesis in Bio Solid Mechanics. Kluwer Academic Publishers. 15. Doblaré M, Garcia JM (2002) Anisotropic bone remodelling model based on a continuum damage-repair theory. J Biomech 35:1-17. 16. Coelho PG, Fernandes PR, Rodrigues HC, Cardoso JB and Guedes JM (2009) Numerical modeling of bone tissue adaptation – A hierarchical approach for bone apparent density and trabecular structure, J. Biomech. 42:830-837. 17. Lucchinetti E (2001) Composite Model of Bone Properties.
These prototypes were made of Polycaprolactone/Hydroxyapatite (PCL/HA). The designs selected were collected as local solutions of the hierarchical bone remodeling model with a local permeability design constraint. These results demonstrate the feasibility of produce scaffolds tailored for a given bone site. Multiscale Modelling of Bone Tissue 31 Fig. 12: Microstructure design models (periodic patterns) and respective prototype fabricated by a SFF technique (These prototypes were fabricated using the facilities of the Scaffold Tissue Engineering Group at the University of Michigan).